Microcrystalline Tests
A microcrystalline test is a presumptive test in which there is a chemical reaction (precipitation reaction) between a substance and a reagent that yields a crystal formation that can be observed microscopically.
The major advantages of a microcrystalline test are: rapid and simple procedure, high sensitivity, can be conducted on unextracted samples, can be utilized to distinguish isomers of certain drugs, and crystals formed are actual crystals of the drug.
MX908 - HIGH PRESSURE MASS SPECTROMETRY
High pressure mass spectrometry is a technique that allows for mass analysis at significantly higher pressure than traditional mass spectrometry (greater than 100 m Torr), reducing the need for complex and large vacuum systems. Reduced vacuum requirements enable the development of smaller and more portable mass spectrometers.
DART-TOF Mass Spectrometry (Preferred Method)
Direct analysis in real time (DART) is an open air ionization technique. The open air source allows sampling of solids, liquids, and gases through surface ionization of the test material. The ion source is coupled to an accurate time-of-flight mass spectrometer giving quick analysis of molecular ions with little to no sample preparation.